Abstract: The required driving signals and the timing relationship of X-ray image sensor required were described. For the driving demand of the series connection of three 64 pixels X-ray image sensor and for the outer synchronization signal generated by mechanical device playing a part in the driving circuit in the practical applications, the programming idea of using VHDL for the required driving signal required was analyzed. The simulation experiments of the driving signals were made with software MAX+plus Ⅱ. The experimental results showed that design of the driving circuit of X-ray image sensor by VHDL was feasible.