Abstract: The in-depth research and comprehensive application of multiple in-line inspection data for long-distance oil and gas pipelines is an important part of pipeline integrity management. In order to carry out data alignment and comparison, the form and content of in-line inspection data have been integrated, the implementation process of alignment and comparison has been sorted out, and the content and methods of alignment and comparison have been studied and analyzed, so as to master important information such as the basic information of pipeline, number and growth of defects, change of pipe position, and so on. And the above-mentioned results are then used to guide pipeline operators to formulate pipeline management plans and risk control measures to provide scientific basis.