Abstract: The difficulty in the design of 450 kV and 600 kV high-frequency X-ray machines is the research and development of high-frequency ultra-high voltage power supply. The high voltage power supply of X-ray machine generally includes power modulator and high voltage generator. Starting from these two aspects, the final breakthrough and innovation point is to use high-frequency inverter power technology to design a high-frequency ultra-high voltage power supply suitable for 450 kV and 600 kV ultra-high voltage X-ray machine, and then design and produce the completely domestic 450 kV and 600 kV high-frequency X-ray machines. Through the experiment comparison, each technical index of this kind of localization high frequency X-ray machine achieves the import level completely, even some parameters are better.