Abstract: The ultrasonic inspection of titanium alloy welds is subjected with low signal-to-noise ratio and high level of tissue noise. The instruments, probes and comparative test blocks used for ultrasonic testing of titanium alloy weld seams are compared with those for carbon steel. The ultrasonic probe, contrast test block, the signal to noise ratio and DAC curve of the titanium alloy weld are also discussed. The results show that the special transverse wave probe of small chip and short cutting edge is obviously effective for the ultrasonic inspection of the weld of titanium alloy, and the detection signal to noise ratio and the coverage range of the weld detection area are improved. The self-made titanium alloy contrast test block meets the standard requirements. The selection of ultrasonic detection probe, the adjustment of the instrument, the sound speed test and the experience of curve making are summarized in the paper, which provides the basis for the NDT process in the later intelligent manufacturing project. The optimized detection technology has been applied in engineering practice and has achieved good results.