Abstract: The full thickness ultrasonic examination according to the requirement of design drawing for nickel base alloy buttering is impossible, because of coarse-grained nickel base alloy and serious attenuation and low signal to noise ratio. There exist distinctions of ultrasonic examination sensitivity in different scanning direction for anisotropic materials. According to the characteristics of the weld, specifically designed examination process of using parallel and vertical reflectors with respect to welding direction is performed to finish the ultrasonic examination of ultra-thick nickel base alloy buttering.